Corrigendum to "Low-intensity focused ultrasound (LIFU) for the treatment of post-traumatic headache (PTH) in veterans: A feasibility study" [Brain Stimulation: Basic, Translational, and Clinical Research in Neuromodulation, vol. 17 (2024), pg. 1290-1292/No. 6].

Introduction

Purpose Transcranial ultrasound stimulation

Study Objective To investigate the feasibility of neuromodulation of the bilateral head of caudate nuclei using low-intensity focused ultrasound (LIFU) as a potential treatment for migraine-like post-traumatic headache.

Animal model / Human subject Humans (veterans), N=2, a 25-year-old male and a 37-year-old female

Disease model Post-traumatic headache (PTH)

MRI or image guidance method MRI-guided and neuronavigation-guided (Localite)

Targeted brain region(s) Caudate head (bilateral)

Outcomes and Safety

Summary of Outcomes LIFU applied to the bilateral caudate heads substantially reduced headache severity, functional impairment, and comorbid PTSD symptoms in one patient, with modest improvements in the other. Successful parameters included a 650 kHz frequency and intensities of 526.97 mW/cm2 and 719.02 mW/cm2

Duration of biological effect < 1month

Safety-related matter No moderate to severe adverse effects or acute intracranial abnormalities were observed. One patient reported a mild, transient headache during sonication that resolved after each session.

Brain Region

Visualization unavailable

Ultrasound Parameters

Ultrasound instrument Brainsonix BX Pulsar 1002

FUS Frequency 650 kHz

FUS Intensity 526.97 mW/cm2; 719.02 mW/cm2

FUS Mode pulsed

Pulse duration 2 ms; 5 ms

Duration of a single FUS session 10 min

Treatment frequency Multiple sessions (5 days)

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