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Figure

Drug delivery with BBB opening

Overview of drug delivery mediated by BBB opening. Low-intensity focused ultrasound is applied to the target area of the BBB to induce cavitation of microbubbles that expands the tight junctions between endothelial cells.

Drug delivery with BBB opening

Explore publications or statistics on 608 articles on Drug delivery with BBB opening

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Papers: 608

Animal Models

Mouse
247
Rat
169
Human
48
Primate
20
Other
14

Target Diseases

Glioma
105
Alzheimer
67
Parkinson
25
Essential Tremor
0
Healthy
240
Other
84

Cargo Types

Aav
42
Protein
78
Small Molecule
28
Nanoparticle
90
Other
185

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Frequent Ultrasound Parameters

Frequency (MHz)
1
Pressure (MPa)
0.3
Pulse Duration (ms)
10
Burst Period (s)
1
Session Duration (min)
2
Pulse Repetition Frequency (Hz)
1
Duty Cycle (%)
1

Ultrasound Parameter Ranges

Frequency Range (MHz)
0.22 – 6
Pressure Range (MPa)
0.088 – 9
Pulse Duration Range (ms)
0.02 – 2000
Burst Period Range (s)
0.001 – 90
Session Duration Range (min)
0.01667 – 30
Pulse Repetition Frequency Range (Hz)
0.01111 – 1000
Duty Cycle Range (%)
0.0075 – 100
Number of relevant publications: 608

Related Publications

Frequently Occurring Parameter Sets

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Group Size Distribution

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Relevant Publications

This section applies only to papers labeled as using a mouse animal model.
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Parameter Selection

Frequency (MHz)
-
Intensity (W/cm²)
-
Pressure (MPa)
-
Pulse Duration (ms)
-
Burst Period (s)
-
Session Duration (min)
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Publications Over Time

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Statistics

Studies

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Studies
608

Review Articles

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Reviews
0