Drug delivery with BBB opening
Overview of drug delivery mediated by BBB opening. Low-intensity focused ultrasound is applied to the target area of the BBB to induce cavitation of microbubbles that expands the tight junctions between endothelial cells.
Drug delivery with BBB opening
Explore publications or statistics on 375 articles on Drug delivery with BBB opening
Animal Models
Mouse
151
Rat
108
Human
28
Primate
11
Other
93
Target Diseases
Glioma
72
Alzheimer
41
Parkinson
12
Essential Tremor
1
Healthy
147
Other
50
Cargo Types
Aav
24
Protein
50
Small Molecule
12
Nanoparticle
55
Other
244
Frequent Ultrasound Parameters
Frequency (MHz)
1.5
1.5
Intensity (W/cm²)
0.5
0.5
Pressure (MPa)
0.3
0.3
Pulse Duration (ms)
10
10
Burst Period (s)
1
1
Session Duration (min)
120
120
Ultrasound Parameter Ranges
Frequency Range (MHz)
-100.0 – 1100.0
-100.0 – 1100.0
Intensity Range (W/cm²)
0.3 – 150.0
0.3 – 150.0
Pressure Range (MPa)
0.0 – 600.0
0.0 – 600.0
Pulse Duration Range (ms)
0.05 – 500.0
0.05 – 500.0
Burst Period Range (s)
0.1 – 1000.0
0.1 – 1000.0
Session Duration Range (min)
1.0 – 1800.0
1.0 – 1800.0
Number of relevant publications:
375
Publications Over Time
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Studies
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318
Review Articles
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57