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Figure

Drug delivery with BBB opening

Overview of drug delivery mediated by BBB opening. Low-intensity focused ultrasound is applied to the target area of the BBB to induce cavitation of microbubbles that expands the tight junctions between endothelial cells.

Drug delivery with BBB opening

Explore publications or statistics on 375 articles on Drug delivery with BBB opening

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Papers: 375

Animal Models

Mouse
151
Rat
108
Human
28
Primate
11
Other
10

Target Diseases

Glioma
72
Alzheimer
41
Parkinson
12
Essential Tremor
1
Healthy
147
Other
48

Cargo Types

Aav
24
Protein
50
Small Molecule
12
Nanoparticle
55
Other
104

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Frequent Ultrasound Parameters

Publications
-
Frequency (MHz)
1.5
Intensity (W/cm²)
0.5
Pressure (MPa)
0.3
Pulse Duration (ms)
10
Burst Period (s)
1
Session Duration (min)
120

Ultrasound Parameter Ranges

Frequency Range (MHz)
-100.0 – 1100.0
Intensity Range (W/cm²)
0.3 – 150.0
Pressure Range (MPa)
0.0 – 600.0
Pulse Duration Range (ms)
0.05 – 500.0
Burst Period Range (s)
0.1 – 1000.0
Session Duration Range (min)
1.0 – 1800.0
Number of relevant publications: 375

Related Publications

This section applies only to papers labeled as using a mouse animal model.
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Frequency (MHz)
-
Intensity (W/cm²)
-
Pressure (MPa)
-
Pulse Duration (ms)
-
Burst Period (s)
-
Session Duration (min)
-

Publications Over Time

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Studies

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Studies
318

Review Articles

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Reviews
57