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Figure

Drug delivery with BBB opening

Overview of drug delivery mediated by BBB opening. Low-intensity focused ultrasound is applied to the target area of the BBB to induce cavitation of microbubbles that expands the tight junctions between endothelial cells.

Drug delivery with BBB opening

Explore publications or statistics on 628 articles on Drug delivery with BBB opening

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Papers: 628

Animal Models

Mouse
242
Rat
164
Human
46
Primate
17
Other
9

Target Diseases

Glioma
110
Alzheimer
69
Parkinson
26
Essential Tremor
0
Healthy
235
Other
99

Cargo Types

Aav
45
Protein
94
Small Molecule
32
Nanoparticle
100
Other
173

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Frequent Ultrasound Parameters

Frequency (MHz)
1.5
ISPTA Intensity (mW/cm²)
-
ISPPA Intensity (W/cm²)
-
Pressure (MPa)
0.3
Pulse Duration (ms)
10
Burst Period (ms)
1
Session Duration (min)
120

Ultrasound Parameter Ranges

Frequency Range (MHz)
-100.0 – 1100.0
ISPTA Intensity Range (mW/cm²)
-
ISPPA Intensity Range (W/cm²)
-
Pressure Range (MPa)
0.0 – 600.0
Pulse Duration Range (ms)
1e-05 – 500.0
Burst Period Range (s)
0.04 – 1000.0
Session Duration Range (min)
1.0 – 1800.0
Number of relevant publications: 628

Related Publications

This section applies only to papers labeled as using a mouse animal model.
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Parameter Selection

Frequency (MHz)
-
Intensity (W/cm²)
-
Pressure (MPa)
-
Pulse Duration (ms)
-
Burst Period (s)
-
Session Duration (min)
-

Publications Over Time

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Studies

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Studies
628

Review Articles

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Reviews
0