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Figure

Drug delivery without BBB opening

[Temporary stand-in figure] Overview of drug delivery without BBB opening. Focused ultrasound is applied to a region outside the BBB to release a BBB-permeable cargo, which passes through the barrier to the brain at the target location.

Drug delivery without BBB opening

Explore publications or statistics on 38 articles on Drug delivery without BBB opening

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Papers: 38

Animal Models

Mouse
13
Rat
10
Human
1
Primate
0
Other
17

Target Diseases

Glioma
9
Alzheimer
1
Parkinson
1
Essential Tremor
0
Healthy
14
Other
8

Cargo Types

Aav
2
Protein
4
Small Molecule
3
Nanoparticle
11
Other
22

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Frequent Ultrasound Parameters

Frequency (MHz)
1.5
Intensity (W/cm²)
0.1
Pressure (MPa)
0.43
Pulse Duration (ms)
10
Burst Period (s)
1
Session Duration (min)
10

Ultrasound Parameter Ranges

Frequency Range (MHz)
0.5 – 650.0
Intensity Range (W/cm²)
0.1 – 500.0
Pressure Range (MPa)
0.1 – 31.7
Pulse Duration Range (ms)
6.7 – 100.0
Burst Period Range (s)
0.2 – 2000.0
Session Duration Range (min)
1.0 – 180.0
Number of relevant publications: 38

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Intensity (W/cm²)
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Pulse Duration (ms)
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Session Duration (min)
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Publications Over Time

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Studies

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Studies
32

Review Articles

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Reviews
6