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Figure

Drug delivery without BBB opening

[Temporary stand-in figure] Overview of drug delivery without BBB opening. Focused ultrasound is applied to a region outside the BBB to release a BBB-permeable cargo, which passes through the barrier to the brain at the target location.

Drug delivery without BBB opening

Explore publications or statistics on 66 articles on Drug delivery without BBB opening

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Papers: 66

Animal Models

Mouse
18
Rat
16
Human
5
Primate
2
Other
1

Target Diseases

Glioma
11
Alzheimer
3
Parkinson
2
Essential Tremor
1
Healthy
22
Other
14

Cargo Types

Aav
4
Protein
10
Small Molecule
4
Nanoparticle
20
Other
21

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Frequent Ultrasound Parameters

Frequency (MHz)
1.5
ISPTA Intensity (mW/cm²)
-
ISPPA Intensity (W/cm²)
-
Pressure (MPa)
1.5
Pulse Duration (ms)
10
Burst Period (ms)
1
Session Duration (min)
3

Ultrasound Parameter Ranges

Frequency Range (MHz)
0.5 – 650.0
ISPTA Intensity Range (mW/cm²)
-
ISPPA Intensity Range (W/cm²)
-
Pressure Range (MPa)
0.1 – 31.7
Pulse Duration Range (ms)
0.06 – 100.0
Burst Period Range (s)
0.01 – 2000.0
Session Duration Range (min)
1.0 – 180.0
Number of relevant publications: 66

Related Publications

This section applies only to papers labeled as using a mouse animal model.
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Parameter Selection

Frequency (MHz)
-
Intensity (W/cm²)
-
Pressure (MPa)
-
Pulse Duration (ms)
-
Burst Period (s)
-
Session Duration (min)
-

Publications Over Time

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Studies

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Studies
66

Review Articles

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Reviews
0