Drug delivery without BBB opening
[Temporary stand-in figure] Overview of drug delivery without BBB opening. Focused ultrasound is applied to a region outside the BBB to release a BBB-permeable cargo, which passes through the barrier to the brain at the target location.
Drug delivery without BBB opening
Explore publications or statistics on 38 articles on Drug delivery without BBB opening
Animal Models
Mouse
13
Rat
10
Human
1
Primate
0
Other
17
Target Diseases
Glioma
9
Alzheimer
1
Parkinson
1
Essential Tremor
0
Healthy
14
Other
8
Cargo Types
Aav
2
Protein
4
Small Molecule
3
Nanoparticle
11
Other
22
Frequent Ultrasound Parameters
Frequency (MHz)
1.5
1.5
Intensity (W/cm²)
0.1
0.1
Pressure (MPa)
0.43
0.43
Pulse Duration (ms)
10
10
Burst Period (s)
1
1
Session Duration (min)
10
10
Ultrasound Parameter Ranges
Frequency Range (MHz)
0.5 – 650.0
0.5 – 650.0
Intensity Range (W/cm²)
0.1 – 500.0
0.1 – 500.0
Pressure Range (MPa)
0.1 – 31.7
0.1 – 31.7
Pulse Duration Range (ms)
6.7 – 100.0
6.7 – 100.0
Burst Period Range (s)
0.2 – 2000.0
0.2 – 2000.0
Session Duration Range (min)
1.0 – 180.0
1.0 – 180.0
Number of relevant publications:
38
Publications Over Time
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Studies
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32
Review Articles
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6