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Figure

Drug delivery without BBB opening

[Temporary stand-in figure] Overview of drug delivery without BBB opening. Focused ultrasound is applied to a region outside the BBB to release a BBB-permeable cargo, which passes through the barrier to the brain at the target location.

Drug delivery without BBB opening

Explore publications or statistics on 58 articles on Drug delivery without BBB opening

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Papers: 58

Animal Models

Mouse
16
Rat
15
Human
4
Primate
2
Other
1

Target Diseases

Glioma
8
Alzheimer
3
Parkinson
2
Essential Tremor
1
Healthy
22
Other
11

Cargo Types

Aav
4
Protein
8
Small Molecule
3
Nanoparticle
16
Other
22

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Frequent Ultrasound Parameters

Frequency (MHz)
1.5
Pressure (MPa)
0.5
Pulse Duration (ms)
10
Burst Period (s)
1
Session Duration (min)
1
Pulse Repetition Frequency (Hz)
1
Duty Cycle (%)
1

Ultrasound Parameter Ranges

Frequency Range (MHz)
0.25 – 2.5
Pressure Range (MPa)
0.1 – 1.8
Pulse Duration Range (ms)
6.7 – 100
Burst Period Range (s)
0.1 – 2
Session Duration Range (min)
0.33333 – 60
Pulse Repetition Frequency Range (Hz)
0.5 – 10
Duty Cycle Range (%)
0.5 – 50
Number of relevant publications: 58

Related Publications

Frequently Occurring Parameter Sets

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Group Size Distribution

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Relevant Publications

This section applies only to papers labeled as using a mouse animal model.
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Parameter Selection

Frequency (MHz)
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Intensity (W/cm²)
-
Pressure (MPa)
-
Pulse Duration (ms)
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Burst Period (s)
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Session Duration (min)
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Publications Over Time

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Studies

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Studies
58

Review Articles

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Reviews
0