[Hypothalamic hamartoma dissection using focused ultrasound under MRI control. The first successful experience in Russia].

Authors: Galimova RM, Illarioshkin SN, Safin SM, Buzaev IV, Nabiullina DI, Krekotin DK, Nurmukhametova SR, Sidorova YA, Akhmadeeva GN, Kashapov FF, Yakupov TZ, Teregulova DR

Treatment of motor disorders by MRI-guided focused ultrasound is an alternative to neuro- and radiosurgery such as stereotactic radiofrequency ablation and thalamotomy with a gamma knife. However, safety, efficacy and feasibility of this technology for intracranial neoplasms are still unclear. The authors report successful hypothalamic hamartoma dissection by MRI-guided focused ultrasound in a 32-year-old woman with drug-resistant gelastic epilepsy and violent laughter and crying attacks. Magnetic resonance imaging revealed type II hypothalamic hamartoma. The last one was detached from surrounding brain tissue by MRI-guided focused ultrasound without side effects. Symptoms regressed immediately after surgery. No laughter and crying attacks were observed throughout 6-month follow-up.

Introduction

Purpose Thermal ablation

Study Objective To report the first successful Russian use of MRI-guided focused ultrasound for dissection of a hypothalamic hamartoma.

Disease model Hypothalamic hamartoma

MRI or image guidance method MRI control

Targeted brain region(s) Hypothalamic Hamartoma

Outcomes and Safety

Summary of Outcomes The report describes the first successful MRI‑guided focused ultrasound dissection of a hypothalamic hamartoma in Russia; clinical/behavioral outcomes are not detailed in the title. No focused ultrasound parameters are provided in the available text.

Safety-related matter The provided text contains only the article title and includes no mention of safety, adverse effects, complications, or their absence; no safety information is reported.

Brain Region

Ultrasound Parameters

Focal Characteristics Focal depth: None; Focal length: None; Aperture size: None

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