Transcranial MRI-Guided Focused Ultrasound: A Review of the Technologic and Neurologic Applications.
Authors: Ghanouni P, Pauly KB, Elias WJ, Henderson J, Sheehan J, Monteith S, Wintermark M
This article reviews the physical principles of MRI-guided focused ultra-sound and discusses current and potential applications of this exciting technology. MRI-guided focused ultrasound is a new minimally invasive method of targeted tissue thermal ablation that may be of use to treat central neuropathic pain, essential tremor, Parkinson tremor, and brain tumors. The system has also been used to temporarily disrupt the blood-brain barrier to allow targeted drug delivery to brain tumors.
Introduction
Purpose
Thermal ablation
Study Objective
To review the physical principles of MR guided focused ultrasound and discuss its current and potential applications for treating brain disorders, including targeted thermal ablation and blood–brain barrier disruption.
MRI or image guidance method
MR-guided (MRI)
Outcomes and Safety
Summary of Outcomes
MR-guided focused ultrasound produces targeted thermal ablation that can treat central neuropathic pain, essential tremor, Parkinsonian tremor, and brain tumors, and can transiently disrupt the blood–brain barrier to enable targeted drug delivery.
Safety-related matter
No safety concerns or adverse effects are mentioned in the provided text.
Brain Region
Ultrasound Parameters
Focal Characteristics
Focal depth: None; Focal length: None; Aperture size: None
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