Ultrasound-mediated blood-brain barrier opening: An effective drug delivery system for theranostics of brain diseases.
Authors: Wang J, Li Z, Pan M, Fiaz M, Hao Y, Yan Y, Sun L, Yan F
Blood-brain barrier (BBB) remains a significant obstacle to drug therapy for brain diseases. Focused ultrasound (FUS) combined with microbubbles (MBs) can locally and transiently open the BBB, providing a potential strategy for drug delivery across the BBB into the brain. Nowadays, taking advantage of this technology, many therapeutic agents, such as antibodies, growth factors, and nanomedicine formulations, are intensively investigated across the BBB into specific brain regions for the treatment of various brain diseases. Several preliminary clinical trials also have demonstrated its safety and good tolerance in patients. This review gives an overview of the basic mechanisms, ultrasound contrast agents, evaluation or monitoring methods, and medical applications of FUS-mediated BBB opening in glioblastoma, Alzheimer's disease, and Parkinson's disease.
Introduction
Purpose
Drug delivery with BBB opening
Study Objective
To evaluate ultrasound-mediated blood–brain barrier opening as an effective drug delivery system for theranostics of brain diseases.
Outcomes and Safety
Summary of Outcomes
Ultrasound-mediated blood–brain barrier opening enhances delivery of therapeutic and diagnostic agents to the brain, improving theranostic efficacy for brain diseases; no specific focused ultrasound parameter sets were reported in the provided text.
Safety-related matter
No safety concerns or adverse effects are mentioned in the provided text.
Brain Region
Ultrasound Parameters
Focal Characteristics
Focal depth: None; Focal length: None; Aperture size: None
We are open to feedback. If you see a mistake or have a suggestion, please contact us.
← Back to Search