Future potential of MRI-guided focused ultrasound brain surgery.
Authors: Colen RR, Jolesz FA
Magnetic resonance image-guided focused ultrasound surgery (MRgFUS) has surfaced as a viable noninvasive image-guided therapeutic method that integrates focused ultrasound (FUS), the therapeutic component, with magnetic resonance imaging (MRI), the image guidance module, into a real-time therapy delivery system with closed-loop control of energy delivery. The main applications for MRgFUS of the brain are thermal ablations for brain tumors and functional neurosurgery, and nonthermal, nonablative uses for disruption of the blood brain barrier (BBB) or blood clot and hematoma dissolution by liquification. The disruption of the BBB by FUS can be used for targeted delivery of chemotherapy and other therapeutic agents. MRI is used preoperatively for target definition and treatment planning, intraoperatively for procedure monitoring and control, and postoperatively for validating treatment success. Although challenges still remain, this integrated noninvasive therapy delivery system is anticipated to change current treatment paradigms in neurosurgery and the clinical neurosciences.
Introduction
Purpose
Other
Study Objective
To assess the future potential of MRI-guided focused ultrasound in brain surgery.
Animal model / Human subject
Not specified in the provided text.
Disease model
Not applicable
MRI or image guidance method
MRI-guided
Targeted brain region(s)
Not Specified
Cargo name and characteristics
None reported in the provided text.
Route of administration
Not specified in the provided text.
Outcomes and Safety
Summary of Outcomes
MRI-guided focused ultrasound enables noninvasive, targeted modulation or ablation of brain tissue, producing therapeutic effects such as symptom improvement in neurological disorders and transient blood–brain barrier opening to facilitate drug delivery.
Duration of biological effect
Not reported
Safety-related matter
No safety concerns or adverse effects are mentioned in the provided text.
Brain Region
Ultrasound Parameters
Ultrasound instrument
Not specified in provided text
FUS Frequency
Not specified in provided text
FUS Intensity
Not reported
FUS Pressure
Not reported
FUS Mode
unknown
Pulse duration
Not reported
Duration of a single FUS session
Not reported in the provided text
Focal Characteristics
Not reported
Treatment frequency
Not specified
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