The recent development of nanoparticles for brain tumor targeting delivery.
Authors: Shevtsov MA
Superparamagnetic iron oxide nanoparticles (SPIONs) have attracted a lot of interest due to their widespread diagnostic and therapeutic applications in neuro-oncology. Functinalization of the particles surface with targeting molecules that recognize tumor receptors might be exploited for the specific brain tumor targeting. Furthermore, multifunctional and/or theranostic SPIONs can be used for simultaneous imaging of cancer and anti-tumor drug delivery. In this review article, we will specifically focus on the application of focused ultrasound and external magnetic field for the facilitation of the intratumoral accumulation of particles.
Introduction
Purpose
Drug delivery with BBB opening
Study Objective
To review recent developments in nanoparticles for targeted delivery to brain tumors.
Animal model / Human subject
Not specified
Disease model
brain tumor
MRI or image guidance method
Not specified in the provided text.
Targeted brain region(s)
Not Specified
Cargo name and characteristics
Nanoparticles — nanoparticle-based delivery systems designed for targeted delivery to brain tumors; specific composition, payload, and properties not specified in the provided text.
Route of administration
Not specified
Outcomes and Safety
Summary of Outcomes
Recent development of nanoparticles enables targeted delivery to brain tumors, improving localization of therapeutic agents.
Safety-related matter
No safety or adverse effects are mentioned in the provided text.
Brain Region
Ultrasound Parameters
FUS Frequency
Not reported
FUS Intensity
Not reported
FUS Pressure
Not reported
FUS Mode
not reported
Pulse duration
Not reported
Duration of a single FUS session
Not reported
Focal Characteristics
Translational focus on targeted nanoparticle-mediated drug delivery to brain tumors
Treatment frequency
Not specified
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