MRI-guided focused ultrasound surgery in the brain: tests in a primate model.
Authors: McDannold N, Moss M, Killiany R, Rosene DL, King RL, Jolesz FA, Hynynen K
MRI-guided focused ultrasound was tested in the brains of rhesus monkeys. Locations up to 4.8 cm deep were targeted. Focal heating was observed in all cases with MRI-derived temperature imaging. Subthreshold heating was observed at the focus when the ultrasound beam was targeted with low power sonications, and in the ultrasound beam path during high-power exposures. Lethal temperature values and histologically confirmed tissue damage were confined to the focal zone (e.g., not in the ultrasound beam path), except when the focus was close to the bone. In that case, damage to the neighboring brain tissue was observed. Focal lesions were observed on histological examination and, in some cases, in MR images acquired immediately after the ultrasound exposures. The capabilities demonstrated in this study will be of benefit for clinical ultrasound therapies in the brain.
Introduction
Purpose
Thermal ablation
Study Objective
To evaluate the feasibility and effects of MRI-guided focused ultrasound surgery in the primate brain.
Animal model / Human subject
Primate (unspecified species), strain None, age None, sex None
Disease model
Healthy
MRI or image guidance method
MRI-guided
Outcomes and Safety
Summary of Outcomes
MRI-guided focused ultrasound in a primate model produced targeted brain lesions demonstrating feasibility of image-guided thermal ablation; specific ultrasound parameters and which ones were successful were None.
Safety-related matter
The provided text contains only the paper title and includes no mention of safety or adverse effects.
Brain Region
Ultrasound Parameters
Focal Characteristics
Focal depth: None; Focal length: None; Aperture size: None
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