Pseudo-CTs from T1-weighted MRI for planning of low-intensity transcranial focused ultrasound neuromodulation: An open-source tool.
Authors: Yaakub SN, White TA, Kerfoot E, Verhagen L, Hammers A, Fouragnan EF
No abstract available
Introduction
Purpose
other
Study Objective
Develop and validate an open-source toolbox to generate pseudo-CTs from T1-weighted MRI for planning low-intensity transcranial focused ultrasound neuromodulation
Animal model / Human subject
none (human imaging data only)
Disease model
healthy
Targeted brain region(s)
None (Simulated On The Whole Brain)
Outcomes and Safety
Summary of Outcomes
Pseudo-CTs achieved MAE 109.8±13.0 HU compared to reference CT. Acoustic simulations using pseudo-CT produced focal pressures statistically equivalent to those using reference CT (0.48±0.04 vs 0.50±0.04 MPa), and were significantly better than binary skull models (0.28±0.05 MPa). Open-source toolbox provided.
Brain Region
Ultrasound Parameters
Ultrasound instrument
none (simulation only)
FUS Pressure
0.48-0.50MPa (simulated)
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