Targeted drug delivery to the brain using focused ultrasound.
Authors: Kinoshita M
Drug delivery to the brain remains a challenging field. The presence of a physiological barrier, the blood-brain barrier (BBB), complicates the delivery of drugs to the brain. Although several methods have been developed for drug delivery to the brain, they have problems such as being invasive or lacking in target specificity. On the other hand, ultrasound has emerged as a treatment method and a diagnostic technology. Several studies have shown the feasibility of using ultrasound for the localized and reversible disruption of the BBB. In this review, I would like to review the recent advancement of ultrasound-induced MRI-guided BBB disruption technique and other methods for delivering drugs to the brain.
Introduction
Purpose
Drug delivery with BBB opening
Study Objective
To evaluate targeted drug delivery to the brain using focused ultrasound.
Outcomes and Safety
Summary of Outcomes
No experimental details are provided in the supplied text, so the paper's reported biological or behavioral effects and any successful focused ultrasound parameters cannot be determined from the excerpt.
Safety-related matter
The provided text contains only the title and does not mention any safety information or adverse effects.
Brain Region
Ultrasound Parameters
Focal Characteristics
Focal depth: None; Focal length: None; Aperture size: None
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