Focused ultrasound therapy: Back to the future.
Authors: Verhagen Metman L, Monje MHG, Obeso JA, Martínez-Fernández R
No abstract available
Introduction
Purpose
Drug delivery with BBB opening
Study Objective
To review the history, current advances, and future prospects of focused ultrasound therapy.
Animal model / Human subject
Humans
Disease model
Parkinson's Disease
MRI or image guidance method
MR-thermography map and structural MRI
Targeted brain region(s)
Parieto-Occipital Cortex And Unilateral Putamen
Target coordinates
not reported
Cargo name and characteristics
neurorestorative molecules
Route of administration
intravenous
Outcomes and Safety
Summary of Outcomes
Focused ultrasound therapy noninvasively produces targeted tissue ablation and reversible neuromodulation (including transient blood–brain barrier opening), yielding therapeutic effects such as tumor destruction, pain relief, and altered neural/behavioral function.
Duration of biological effect
Not reported
Safety-related matter
Small inaccuracies in targeting and overall execution of an ablative procedure may lead to irreversible deficits.
Brain Region
Ultrasound Parameters
Ultrasound instrument
MRgFUS (magnetic resonance–guided high-intensity focused ultrasound)
FUS Frequency
220 kHz
FUS Intensity
100W
FUS Pressure
Not reported
FUS Mode
pulsed
Pulse duration
Not reported
Duration of a single FUS session
Not stated in the provided text
Focal Characteristics
Not specified
Treatment frequency
Not specified
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