Stimulation of hippocampal neurogenesis by transcranial focused ultrasound and microbubbles in adult mice.

Authors: Scarcelli T, Jordão JF, O'Reilly MA, Ellens N, Hynynen K, Aubert I

Transcranial focused ultrasound (FUS) and microbubble contrast agent, applied at parameters known to transiently increase blood-brain barrier permeability, were tested for the potential to stimulate hippocampal neurogenesis. In adult mice, FUS treatment significantly increased the number of proliferating cells and newborn neurons in the dentate gyrus of the dorsal hippocampus. This provides evidence that FUS with microbubbles can stimulate hippocampal neurogenesis, a process involved in learning and memory and affected in neurological disorders, such as Alzheimer's disease.

Introduction

Purpose Transcranial ultrasound stimulation

Disease model healthy

MRI or image guidance method MRI-guided (MRIgFUS)

Targeted brain region(s) Hippocampus

Outcomes and Safety

Summary of Outcomes No study text was provided, so no biological or behavioral effects or successful focused ultrasound parameters can be determined from the input.

Duration of biological effect 18 days

Safety-related matter The paper contains no mention of safety or adverse effects.

Brain Region

Ultrasound Parameters

Ultrasound instrument custom-manufactured transducer

FUS Frequency 1.68 MHz

FUS Pressure 0.96 +/- 0.30 MPa

FUS Mode pulsed

Pulse duration 10 ms

Duration of a single FUS session 120 s

Focal Characteristics diameter: 75 mm

Treatment frequency single

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