A multitheragnostic nanobubble system to induce blood-brain barrier disruption with magnetically guided focused ultrasound.

Authors: Huang HY, Liu HL, Hsu PH, Chiang CS, Tsai CH, Chi HS, Chen SY, Chen YY

A novel magnetically guidable nanobubble is designed for disrupting the blood-brain barrier (BBB) by combining magnetic guidance with focused ultrasound in vivo. The magnetic-nanobubble platform also demonstrates the potential to serve as a unique theranostic tool via performing focused ultrasound (FUS)-induced BBB disruption and magnetic resonance imaging (MRI)/ultrasound dual-modality contrast-agent imaging to improve the drug delivery of therapeutic substances or gene therapy into the central nervous system.

Introduction

Purpose Drug delivery with BBB opening

Study Objective To develop a multitheragnostic nanobubble system for magnetically guided focused ultrasound-induced disruption of the blood-brain barrier.

MRI or image guidance method Magnetically guided

Outcomes and Safety

Summary of Outcomes A magnetically guided focused ultrasound combined with a multitheragnostic nanobubble system induced blood–brain barrier disruption; no specific focused ultrasound parameters were reported in the provided text.

Safety-related matter No safety or adverse effects were mentioned in the provided text.

Brain Region

Visualization unavailable

Ultrasound Parameters

Focal Characteristics Focal depth: None; Focal length: None; Aperture size: None

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