Signaled drug delivery and transport across the blood-brain barrier.
Authors: Hinow P, Radunskaya A, Mackay SM, Reynolds JN, Schroeder M, Tan EW, Tucker IG
We use a mathematical model to describe the delivery of a drug to a specific region of the brain. The drug is carried by liposomes that can release their cargo by application of focused ultrasound (US). Thereupon, the drug is absorbed through the endothelial cells that line the brain capillaries and form the physiologically important blood-brain barrier (BBB). We present a compartmental model of a capillary that is able to capture the complex binding and transport processes the drug undergoes in the blood plasma and at the BBB. We apply this model to the delivery of levodopa (L-dopa, used to treat Parkinson's disease) and doxorubicin (an anticancer agent). The goal is to optimize the delivery of drug while at the same time minimizing possible side effects of the US.
Introduction
Purpose
Drug delivery WITHOUT BBB opening
Study Objective
To develop and evaluate a signal-triggered drug delivery strategy to enable and control transport of therapeutic agents across the blood–brain barrier.
Disease model
healthy
Outcomes and Safety
Summary of Outcomes
No experimental results or descriptions were provided in the supplied text; unable to summarize biological or behavioral effects of the intervention.
Brain Region
Ultrasound Parameters
Focal Characteristics
No details about focal size, depth, or beam diameter are provided in the text.
Treatment frequency
unclear
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