Preliminary study on Low Intensity Focused Ultrasound system For neuromodulation.
Authors: Ju Hyung Lee, Hyun Ki Hong, Byeong-Wook Song, Yu Jin Jung, Young Cheol Na, Nam Hyun Kim, Bong-Soo Kim
A Prototype Low Intensity Focused Ultrasound for brain targeting in a rat model was developed and tested. Accordingly, were evaluated low intensity focused ultrasound accuracy and performance. By utilizing the Rat Brain, no death or necrosis of cells, it was confirmed that the energy is gathered at that targeted.
Introduction
Purpose
Transcranial ultrasound stimulation
Study Objective
To develop and evaluate a prototype low-intensity focused ultrasound system for targeted brain neuromodulation in rats.
Animal model / Human subject
Rat
Disease model
Healthy
Outcomes and Safety
Summary of Outcomes
The prototype LIFU system successfully focused energy at the intended target in rat brain tissue, and no cell death or necrosis.
Safety-related matter
No death or tissue necrosis observed in rat brain following LIFU exposure.
Brain Region
Ultrasound Parameters
Ultrasound instrument
Prototype Low Intensity Focused Ultrasound
Focal Characteristics
Focal depth: None; Focal length: None; Aperture size: None
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