Targeted Delivery of DNA-Au Nanoparticles across the Blood-Brain Barrier Using Focused Ultrasound.
Authors: Chan TG, Morse SV, Copping MJ, Choi JJ, Vilar R
Nanoparticles have been widely studied as versatile platforms for in vivo imaging and therapy. However, their use to image and/or treat the brain is limited, as they are often unable to cross the blood-brain barrier (BBB). To overcome this problem, herein we report the use of focused ultrasound in vivo to successfully deliver DNA-coated gold nanoparticles to specific locations in the brains of mice.
Introduction
Purpose
Drug delivery with BBB opening
Study Objective
To evaluate whether focused ultrasound can mediate targeted delivery of DNA-functionalized gold nanoparticles across the blood–brain barrier.
Cargo name and characteristics
DNA-functionalized gold nanoparticles (DNA-Au nanoparticles): gold nanoparticle core conjugated with DNA oligonucleotides; nanoparticle cargo
Outcomes and Safety
Summary of Outcomes
Focused ultrasound enabled targeted delivery of DNA-conjugated gold nanoparticles across the blood–brain barrier, increasing nanoparticle access to the brain. The provided text contains no details on specific focused ultrasound parameters tested or found successful.
Safety-related matter
The provided text contains only the paper title and includes no mention of safety or adverse effects. No adverse effects are reported in the supplied excerpt.
Brain Region
Ultrasound Parameters
Focal Characteristics
Focal depth: None; Focal length: None; Aperture size: None
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