Research hotspots and frontiers of essential tremor from 2013 to 2023: a visualization analysis based on CiteSpace.
Authors: Zhang L, Cui S, Xi X, Bi H, Huang B
ET, one of the most prevalent neurological disorders, presents a significant challenge in terms of disability. Despite the growing focus on ET in recent years, comprehensive bibliometric analysis has been lacking. This study delves into essential tremor research covering the period from 2013 to 2023, utilizing the Web of Science (WOS) database. Employing CiteSpace for quantitative analysis, it examines an array of metrics including annual publication trends, contributions from countries and institutions, authorship patterns, key terminologies, and patterns of reference co-citation. The primary objective is to use CiteSpace for a detailed visual exploration of the literature over the last decade, pinpointing the evolving landscape and key areas of focus in essential tremor research, and thus providing a foundation for future investigative endeavors. There were 2,224 literary works included in all. The amount of published works has been steadily rising in recent years. Of them, the majority originate from the United States, Louis, Elan D. is the publisher of the most publications (161 articles), and Movement Disorders is the journal that receives the most citations. The key words contribution and co-cited literatures suggest that the main research hotspots in recent years are the physiological and pathological mechanism of essential tremor, the determination of optimal targets for deep brain stimulation (DBS) and surgery transcranial magnetic resonance-guided focused ultrasound (MRgFUS) in the surgical management of essential tremor and the innovative research of botulinum toxin administration method.
Introduction
Purpose
Other
Study Objective
To use CiteSpace to conduct a comprehensive bibliometric and visual analysis of essential tremor research from 2013 to 2023 to identify evolving trends and key research hotspots.
Animal model / Human subject
literature search
Disease model
Essential tremor
MRI or image guidance method
Transcranial magnetic resonance-guided focused ultrasound (MRgFUS)
Targeted brain region(s)
Not Provided
Target coordinates
not provided
Cargo name and characteristics
Botulinum toxin (protein neurotoxin)
Route of administration
not provided
Outcomes and Safety
Summary of Outcomes
Bibliometric analysis shows essential tremor is linked to cerebellar degeneration and network dysfunction, surgical treatments (DBS—with some evidence favoring PSA over VIM—and MRgFUS thalamotomy) and precision botulinum toxin protocols (Yale protocol and kinematic-guided dosing) reduce tremor though MRgFUS can cause notable sensory/motor/gait adverse effects; no specific focused‑ultrasound sonication parameters were reported as successful.
Duration of biological effect
12–24 months
Safety-related matter
The paper reports notable adverse effects: MRgFUS thalamotomy has been associated with permanent deficits (sensory problems, weakness, gait instability) in up to ~15% in some reports and sensory/motor/gait abnormalities in studies reporting rates up to ~40%; DBS carries stimulation‑related complications such as dysarthria and gait ataxia (with similar incidence between ViM and PSA targets though PSA may have fewer stimulation‑related complications); and botulinum toxin injections can cause muscle weakness and, for sternocleidomastoid (head/neck) injections, neck pain and swallowing difficulties in over 50% of patients, whereas precision injection protocols (Yale protocol, kinematic assessment) have been shown to reduce side effects.
Brain Region
Ultrasound Parameters
Ultrasound instrument
Not provided
FUS Frequency
Not provided
FUS Intensity
Not provided
FUS Pressure
Not provided
FUS Mode
Not provided
Pulse duration
Not provided
Duration of a single FUS session
Not provided
Focal Characteristics
Not provided
Treatment frequency
not provided
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