Biological effects of blood-brain barrier disruption using a focused ultrasound.
Authors: Han M, Hur Y, Hwang J, Park J
With focused ultrasound (FUS) and microbubbles, BBB can be transiently disrupted with a localized and non-invasive approach. BBB disruption induced by FUS has made progressions to move forward on delivery of therapeutic agents into a brain in a specific area of brain for better treatment of neurological diseases. In addition to be used as an improvement of drug delivery, BBB disruption has been found to induce biological effects such as a clearance of protein aggregation which cause Alzheimer's disease, regulation of proteins which facilitate drug uptake, and modulation of neuronal function and neurogenesis. In this review, we discuss overview about the principles of BBB opening with FUS and milestones in these biological effects of FUS-induced BBB disruption.
Introduction
Purpose
Drug delivery with BBB opening
Study Objective
To review the principles of focused ultrasound-induced blood–brain barrier opening and summarize the key biological effects and milestones of this technique.
Disease model
Alzheimer's disease
Outcomes and Safety
Summary of Outcomes
Focused ultrasound (FUS) with microbubbles transiently and locally opens the blood–brain barrier and induces biological effects including clearance of protein aggregates relevant to Alzheimer’s disease, regulation of proteins that facilitate drug uptake, and modulation of neuronal function and neurogenesis; the review summarizes principles and milestones but does not report specific FUS parameter sets identified as successful.
Safety-related matter
The excerpt does not report any safety issues or adverse effects; it describes FUS-induced BBB disruption as transient, localized, and non-invasive.
Brain Region
Ultrasound Parameters
Focal Characteristics
Focal depth: None; Focal length: None; Aperture size: None
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