Modulating the Blood-Brain Barrier: A Comprehensive Review.
Authors: Whelan R, Hargaden GC, Knox AJS
The highly secure blood-brain barrier (BBB) restricts drug access to the brain, limiting the molecular toolkit for treating central nervous system (CNS) diseases to small, lipophilic drugs. Development of a safe and effective BBB modulator would revolutionise the treatment of CNS diseases and future drug development in the area. Naturally, the field has garnered a great deal of attention, leading to a vast and diverse range of BBB modulators. In this review, we summarise and compare the various classes of BBB modulators developed over the last five decades-their recent advancements, advantages and disadvantages, while providing some insight into their future as BBB modulators.
Introduction
Purpose
Drug delivery with BBB opening
Study Objective
To review and compare the various classes of blood–brain barrier (BBB) modulators developed over the past five decades, summarizing their recent advances, advantages and disadvantages, and future prospects.
Outcomes and Safety
Summary of Outcomes
The review concludes that diverse classes of blood–brain barrier (BBB) modulators developed over five decades can transiently increase BBB permeability to broaden CNS drug delivery, potentially enabling treatment with larger or non‑lipophilic therapeutics, and summarizes their recent advances, advantages, and disadvantages. The paper does not report testing or identifying specific focused ultrasound parameters.
Safety-related matter
No specific safety concerns or adverse effects are mentioned in the provided text; the authors note the need for a "safe and effective" BBB modulator and discuss advantages and disadvantages but report no observed adverse effects.
Brain Region
Ultrasound Parameters
Focal Characteristics
Focal depth: None; Focal length: None; Aperture size: None
We are open to feedback. If you see a mistake or have a suggestion, please contact us.
← Back to Search