Magnetic Resonance-Guided focused ultrasound surgery for Parkinson's disease: A mini-review and comparison between deep brain stimulation.

Authors: Ko TH, Lee YH, Chan L, Tsai KW, Hong CT, Lo WL

Magnetic resonance-guided focused ultrasound (MRgFUS) is a new surgical treatment for Parkinson's disease (PD). Previous experience with radiofrequency lesionectomy and deep brain stimulation (DBS) has identified several candidate targets for MRgFUS intended to alleviate the motor symptoms of PD. The main advantage of MRgFUS is that it is incisionless. MRgFUS has certain limitations and is associated with adverse effects. The present study reviews the literature on conventional surgical interventions for PD, discusses recent studies on MRgFUS, and the comparison between DBS and MRgFUS for PD. The reviews aims to provide an essential reference for neurologists to select the appropriate treatments for patients with PD.

Introduction

Purpose Thermal ablation

Study Objective To review the use of magnetic resonance-guided focused ultrasound surgery for Parkinson's disease and compare its outcomes, benefits, and risks with deep brain stimulation.

Disease model Parkinson's disease

Outcomes and Safety

Summary of Outcomes MR-guided focused ultrasound (MRgFUS) produced rapid and significant improvements in Parkinsonian motor symptoms—especially tremor—across reviewed studies, with successful procedures reported for unilateral VIM thalamotomy; the review did not systematically compare or list specific ultrasound sonication parameter sets.

Safety-related matter No safety concerns or adverse effects are mentioned in the provided text.

Brain Region

Visualization unavailable

Ultrasound Parameters

Focal Characteristics Focal depth: None; Focal length: None; Aperture size: None

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