Nanotherapeutic treatment of the invasive glioblastoma tumor microenvironment.

Authors: Pandey N, Anastasiadis P, Carney CP, Kanvinde PP, Woodworth GF, Winkles JA, Kim AJ

Glioblastoma (GBM) is the most common malignant adult brain cancer with no curative treatment strategy. A significant hurdle in GBM treatment is effective therapeutic delivery to the brain-invading tumor cells that remain following surgery within functioning brain regions. Developing therapies that can either directly target these brain-invading tumor cells or act on other cell types and molecular processes supporting tumor cell invasion and recurrence are essential steps in advancing new treatments in the clinic. This review highlights some of the drug delivery strategies and nanotherapeutic technologies that are designed to target brain-invading GBM cells or non-neoplastic, invasion-supporting cells residing within the GBM tumor microenvironment.

Introduction

Purpose Drug delivery WITHOUT BBB opening

Study Objective To review drug delivery strategies and nanotherapeutic technologies aimed at targeting brain-invading glioblastoma cells and non-neoplastic, invasion-supporting cells in the tumor microenvironment.

Disease model Glioblastoma

Outcomes and Safety

Summary of Outcomes The review summarizes drug delivery and nanotherapeutic strategies designed to target brain‑invading glioblastoma cells and non‑neoplastic, invasion‑supporting cells in the tumor microenvironment to improve therapeutic delivery and reduce recurrence. No focused ultrasound parameters were tested or reported as successful.

Safety-related matter The text contains no mention of safety concerns or adverse effects.

Brain Region

Visualization unavailable

Ultrasound Parameters

Focal Characteristics focal depth: None; focal length: None; aperture size: None

We are open to feedback. If you see a mistake or have a suggestion, please contact us.