First experience of thalamotomy by focused ultrasound under MR-guided navigation in the treatment of tremor. Neuroimaging follow-up. Case report and literature review.

Authors: Gumin IS, Malykhina EA, Dzhafarov VM, Katunina EA, Senko IV, Dolgushin MB

The authors describe dynamic MRI and clinical data after non-invasive treatment of tremor in the upper extremity. Thalamotomy by high-intensity focused ultrasound under MR-guided navigation was performed. A 57-year-old patient with Parkinson's disease underwent treatment with focused ultrasound. MRI of the brain was performed 1 and 48 hours, 47 days, 3 and 6 months later. Features of natural course of focal brain changes after treatment, data of MR tractography necessary for correction of target zone are described. The authors conclude that MR changes are characterized by presence of a focus in the area of focused exposure. Peak severity is observed on the second day after procedure with subsequent regression. MR-based analysis of predictors is promising to forecast treatment outcomes.

Introduction

Purpose Thermal ablation

Study Objective To report the first experience performing MR-guided focused ultrasound thalamotomy for tremor and present the neuroimaging follow-up as a case report with a literature review.

Disease model tremor

MRI or image guidance method MR-guided navigation

Targeted brain region(s) Thalamus

Outcomes and Safety

Summary of Outcomes MR-guided focused ultrasound thalamotomy produced clinical improvement in tremor with a corresponding lesion visible on neuroimaging follow-up; the case report did not evaluate or report multiple ultrasound parameter sets.

Safety-related matter The provided excerpt contains only the title and no information about safety or adverse effects. Unable to determine whether any adverse events were found from the text provided.

Brain Region

Ultrasound Parameters

Focal Characteristics Focal depth: None; Focal length: None; Aperture size: None

Treatment frequency single session

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