Pitt Shield

Innovative approaches in the perioperative care of the cardiac surgical patient in the operating room and intensive care unit.

Authors: Denault A, Lamarche Y, Rochon A, Cogan J, Liszkowski M, Lebon JS, Ayoub C, Taillefer J, Blain R, Viens C, Couture P, Deschamps A

Perioperative care for cardiac surgery is undergoing rapid evolution. Many of the changes involve the application of novel technologies to tackle common challenges in optimizing perioperative management. Herein, we illustrate recent advances in perioperative management by focusing on a number of novel components that we judge to be particularly important. These include: the introduction of brain and somatic oximetry; transesophageal echocardiographic hemodynamic monitoring and bedside focused ultrasound; ultrasound-guided vascular access; point-of-care coagulation surveillance; right ventricular pressure monitoring; novel inhaled treatment for right ventricular failure; new approaches for postoperative pain management; novel approaches in specialized care procedures to ensure quality control; and specific approaches to optimize the management for postoperative cardiac arrest. Herein, we discuss the reasons that each of these components are particularly important in improving perioperative care, describe how they can be addressed, and their impact in the care of patients who undergo cardiac surgery.

Introduction

Purpose Drug delivery with BBB opening
Study Objective To explore whether FUS opening BBB can reduce Aβ plaques by activating autophagy without exogenous drugs.
Animal model / Human subject mouse, TgCRND8, 4 months, not reported
Disease model Alzheimer's disease
MRI or image guidance method MRI-guided
Targeted brain region(s) Hippocampus
Target coordinates not reported

Outcomes and Safety

Summary of Outcomes 1.68 MHz FUS-induced BBB opening reduced Aβ plaque pathology by 20% through activation of the autophagy-lysosome pathway.
Duration of biological effect 48 h
Safety-related matter No tissue damage, microhemorrhage, or edema reported at 0.3 MPa.

Brain Region

Ultrasound Parameters

FUS Frequency RK-100, FUS Instruments
FUS Intensity 1.68 MHz
FUS Pressure not reported
FUS Mode pulsed
Pulse duration 10 ms
Duration of a single FUS session 120 s
Focal Characteristics focal depth: 12 mm
Treatment frequency single session

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