Potential of sonobiopsy as a novel diagnosis tool for brain cancer.

Authors: Yan L, Fu K, Li L, Li Q, Zhou X

Brain tumors have a poor prognosis. Early, accurate diagnosis and treatment are crucial. Although brain surgical biopsy can provide an accurate diagnosis, it is highly invasive and risky and is not suitable for follow-up examination. Blood-based liquid biopsies have a low detection rate of tumor biomarkers and limited evaluation ability due to the existence of the blood-brain barrier (BBB). The BBB is composed of brain capillary endothelial cells through tight junctions, which prevents the release of brain tumor markers to the human peripheral circulation, making it more difficult to diagnose, predict prognosis, and evaluate therapeutic response through brain tumor markers than other tumors. Focused ultrasound (FUS)-enabled liquid biopsy (sonobiopsy) is an emerging technique using FUS to promote the release of tumor markers into the circulatory system and cerebrospinal fluid, thus facilitating tumor detection. The feasibility and safety data from both animal models and clinical trials support sonobiopsy as a great potential in the diagnosis of brain diseases.

Introduction

Purpose Sonobiopsy

Study Objective To review and evaluate focused ultrasound-enabled liquid biopsy (sonobiopsy) as a method to transiently disrupt the blood-brain barrier and promote release of brain tumor biomarkers into blood and cerebrospinal fluid to improve noninvasive diagnosis.

Disease model brain tumor

Outcomes and Safety

Summary of Outcomes Focused ultrasound (sonobiopsy) transiently increases release of brain tumor biomarkers into the circulatory system and cerebrospinal fluid, improving tumor detection with demonstrated feasibility and safety in animal models and early clinical trials. The paper does not report specific successful FUS parameter sets; it notes ultrasonic power, irradiation time, and probe size as parameters requiring further optimization.

Safety-related matter The authors state that feasibility and safety data from animal models and clinical trials support sonobiopsy and do not report specific adverse effects; they caution about technical challenges and call for more clinical studies to ensure effective and safe implementation.

Brain Region

Visualization unavailable

Ultrasound Parameters

Focal Characteristics Focal depth: None; Focal length: None; Aperture size: None

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