Advances in ultrasound-mediated brain drug delivery.

Authors: Wang Y, Wen Q, Hu A, Chen X, Liu J, Lin J, Xie Y

The primary objective of this review is to summarize research cases and recent advances in ultrasound technology for overcoming the blood-brain barrier (BBB) and facilitating drug delivery to the brain, thereby providing insights to promote research on enhancing drug permeation across the BBB. This review summarizes recent advances in focused ultrasound combined with microbubbles to enhance BBB permeability for brain-targeted drug delivery. It covers the mechanisms by which ultrasound and microbubbles open the BBB, the factors influencing this process, and their applications in brain diseases. Finally, existing challenges in the field are highlighted, and the prospects for clinical translation are discussed. Ultrasound combined with microbubble technology can safely, non-invasively, and reversibly open the BBB and deliver drugs, offering novel strategies and methods for the treatment of brain diseases.

Introduction

Purpose Drug delivery with BBB opening

Study Objective To review recent advances in ultrasound-mediated strategies for delivering therapeutics to the brain, including mechanisms, technologies, and translational progress.

Outcomes and Safety

Summary of Outcomes The paper reviews that ultrasound-mediated blood–brain barrier opening (typically using focused ultrasound with microbubbles) enhances delivery of therapeutics to the brain and can improve biological and behavioral outcomes in preclinical studies. The provided text contains no specific experimental comparison of focused‑ultrasound parameters or reported successful parameter sets.

Safety-related matter The provided text contains no mention of safety or adverse effects.

Brain Region

Visualization unavailable

Ultrasound Parameters

Focal Characteristics Focal depth: None; Focal length: None; Aperture size: None

We are open to feedback. If you see a mistake or have a suggestion, please contact us.