[Characteristics of the formation of local destructive foci in brain tissues exposed to focused ultrasound].

Authors: Vykhodtseva NI, Adrianov OS, Konopatskaia II, Solontsova LV

Local lesions produced in the different brain structures by focused ultrasound were investigated. It was revealed that the blood flow volume velocity had a considerable influence on temperature distribution in the focal area and on the threshold doses and lesion dimensions. Calculation of the lesion diameters on the basis of a purely heat model shows rather good accordance with the experimental data for the large hemispherical cortex and thalamic nuclei with a sufficiently long radiation time. A correlation was found between the subharmonic component of cavitation noise and appearance of the cavities, ruptures, and local hemorrhages located mainly on the boundaries between different cerebral tissues.

Introduction

Purpose Other

Study Objective To characterize how focused ultrasound induces the formation of local destructive foci in brain tissues.

Animal model / Human subject not reported

Disease model healthy

Targeted brain region(s) Not Reported

Outcomes and Safety

Summary of Outcomes FUS exposure produced localized destructive foci in brain tissue; lesion characteristics depended on sonication parameters.

Duration of biological effect not reported

Safety-related matter Tissue destruction was the primary outcome of interest; no safety assessment reported.

Brain Region

Ultrasound Parameters

Ultrasound instrument focused ultrasound transducer

FUS Frequency not reported

FUS Intensity not reported

FUS Pressure not reported

FUS Mode not reported

Pulse duration not reported

Duration of a single FUS session not reported

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