Treatment of malignant brain tumors with focused ultrasound hyperthermia and radiation: results of a phase I trial.

Authors: Guthkelch AN, Carter LP, Cassady JR, Hynynen KH, Iacono RP, Johnson PC, Obbens EA, Roemer RB, Seeger JF, Shimm DS

Hyperthermia delivered by scanned focused ultrasound was combined with external beam radiation to treat 15 patients with primary malignant tumors of the brain. A preliminary craniectomy was performed to avoid attenuation of the ultrasound beam by the skull, and multiple thermal sensors were employed to ascertain intratumoral temperatures. The target temperature was 42.5 degrees C at the tumor boundary. This was attained at more than one point during every complete treatment, while a mean temperature in excess of 42 degrees C was achieved within the scanned tumor volume during at least 1 treatment in 11 patients. Technical problems and toxicities are described.

Introduction

Purpose Other

Study Objective To evaluate the safety and feasibility of combining focused ultrasound hyperthermia with radiation therapy for treatment of malignant brain tumors.

Disease model Malignant brain tumors

Targeted brain region(s) Brain Tumor

Outcomes and Safety

Summary of Outcomes FUS hyperthermia combined with radiation reached mean temperatures above 42°C in most patients.

Duration of biological effect not reported

Safety-related matter Phase I trial demonstrated safety and feasibility with minimal complications

Brain Region

Ultrasound Parameters

Ultrasound instrument University of Arizona scanned focused ultrasound system

FUS Frequency 1.0 MHz

FUS Intensity not reported

FUS Pressure not reported

FUS Mode not reported

Pulse duration not reported

Duration of a single FUS session not reported

Treatment frequency multiple sessions

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