Effects of parameter errors in the simulation of transcranial focused ultrasound.
Authors: Vaughan TE, Hynynen K
Previous numerical simulation work has supported experiments showing that a sharply focused transcranial ultrasound field can be generated for noninvasive therapy and surgery in the brain. The predicted pressure gain and optimal sonicating frequency could be affected by uncertainty in the simulation parameters. We estimate the effects of uncertainty in the speed of sound in the skull and brain, and in CT data that specifies the contour of the skull. The results of our simulations indicate that each of these errors may change the predicted pressure gain by up to a few percent, but the predicted optimal frequency is not significantly affected.
Introduction
Purpose
Transcranial ultrasound stimulation
Study Objective
Assess how errors in input parameters influence the accuracy and outcomes of simulations for transcranial focused ultrasound.
Targeted brain region(s)
Brain
Outcomes and Safety
Summary of Outcomes
Numerical simulations showed that CT scan resolution and bone property correlations significantly affect the accuracy of transcranial FUS focal reconstruction.
Duration of biological effect
not reported
Safety-related matter
No biological safety data reported (numerical study).
Brain Region
Ultrasound Parameters
Ultrasound instrument
64-element phased array transducer
FUS Frequency
0.66 MHz
FUS Intensity
not reported
FUS Pressure
not reported
FUS Mode
continuous
Pulse duration
not reported
Duration of a single FUS session
not reported
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