Signaled drug delivery and transport across the blood-brain barrier.
Authors: Hinow P, Radunskaya A, Mackay SM, Reynolds JN, Schroeder M, Tan EW, Tucker IG
We use a mathematical model to describe the delivery of a drug to a specific region of the brain. The drug is carried by liposomes that can release their cargo by application of focused ultrasound (US). Thereupon, the drug is absorbed through the endothelial cells that line the brain capillaries and form the physiologically important blood-brain barrier (BBB). We present a compartmental model of a capillary that is able to capture the complex binding and transport processes the drug undergoes in the blood plasma and at the BBB. We apply this model to the delivery of levodopa (L-dopa, used to treat Parkinson's disease) and doxorubicin (an anticancer agent). The goal is to optimize the delivery of drug while at the same time minimizing possible side effects of the US.
Introduction
Purpose
Drug delivery WITHOUT BBB opening
Study Objective
To develop and evaluate a signal-triggered drug delivery strategy to enable and control transport of therapeutic agents across the blood–brain barrier.
Animal model / Human subject
Not specified in the provided text.
Disease model
healthy
MRI or image guidance method
Not specified in provided text
Targeted brain region(s)
Not Specified
Cargo name and characteristics
Not specified in the provided text
Route of administration
not specified in the provided text
Outcomes and Safety
Summary of Outcomes
No experimental results or descriptions were provided in the supplied text; unable to summarize biological or behavioral effects of the intervention.
Duration of biological effect
Not reported
Safety-related matter
No mention of safety, tissue damage, or adverse effects in the provided text.
Brain Region
Ultrasound Parameters
Ultrasound instrument
Not reported in provided text.
FUS Frequency
Not specified in provided text
FUS Intensity
Not specified
FUS Pressure
Not stated in provided text.
FUS Mode
not specified
Pulse duration
not reported in provided text
Duration of a single FUS session
Not stated in the provided text
Focal Characteristics
No details about focal size, depth, or beam diameter are provided in the text.
Treatment frequency
unclear
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