Toward focused ultrasound neuromodulation in deep brain stimulator implanted patients: Ex-vivo thermal, kinetic and targeting feasibility assessment.
Authors: Sarica C, Fomenko A, Nankoo JF, Darmani G, Vetkas A, Yamamoto K, Lozano AM, Chen R
No abstract available
Introduction
Purpose
Other
Study Objective
To evaluate the feasibility of transcrainial FUS in the presence of deep brain stimulation leads by accessing heating, motion, and spatial targeting accuracy in phamtom models.
Disease model
Deep brain stimulator implanted patients
Outcomes and Safety
Summary of Outcomes
Ex‑vivo experiments demonstrated that focused ultrasound can be targeted near deep brain stimulator implants with controllable thermal and kinetic effects, indicating feasibility of neuromodulation in this setting.
Safety-related matter
Temperature rise (max +1.67C), the author state this is below brain tissue damage temp. DBS lead motion was found to be < 0.06 mm, not a safety concern.
Brain Region
Ultrasound Parameters
Ultrasound instrument
NeuroFus CTX-500 (four channel TUS transducer, BrainBox Ltd, UK)
FUS Frequency
500 kHz
FUS Intensity
ISPPA: 30 W/cm2; ISPTA: 15 W/cm2
FUS Mode
pulsed
Pulse duration
0.5 ms
Focal Characteristics
Focal depth: 60 mm; Focal length: None; Aperture size: None
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