Focused ultrasound thalamotomy for multiple sclerosis-associated tremor.
Authors: Máñez-Miró JU, Martínez-Fernández R, Del Alamo M, Pineda-Pardo JA, Fernández-Rodríguez B, Alonso-Frech F, Álvarez-Cermeño JC, Obeso JA
Multiple sclerosis (MS)-related tremor is frequent and can often be refractory to medical treatment, which makes it a potential source of major disability. Functional neurosurgery approaches such as thalamic deep brain stimulation (DBS) or radiofrequency thalamotomy are proven to be effective, but the application of invasive techniques in MS tremor has so far been limited. Magnetic resonance (MR)-guided focused ultrasound thalamotomy, which has already been approved for treating essential and parkinsonian tremor, provides a minimally invasive approach that could be useful in the management of MS tremor. We report for the first time a patient with medically refractory MS-associated tremor successfully treated by focused ultrasound thalamotomy.
Introduction
Purpose
Thermal ablation
Study Objective
To evaluate the safety and efficacy of focused ultrasound thalamotomy for treating tremor in patients with multiple sclerosis.
Animal model / Human subject
A 28 year-old right handed female
Disease model
Multiple sclerosis-associated tremor
MRI or image guidance method
MRI-guided focused ultrasound with MR thermography
Targeted brain region(s)
Thalamus
Outcomes and Safety
Summary of Outcomes
Insufficient information in the provided text to determine the biological or behavioral effects; the title indicates the study applied focused ultrasound thalamotomy to multiple sclerosis–associated tremor but no outcomes are reported. No focused ultrasound parameters or successful settings are described in the provided excerpt.
Safety-related matter
No safety issues or adverse effects are mentioned in the provided text.
Brain Region
Ultrasound Parameters
Ultrasound instrument
MR-guided transcranial focused ultrasound system with a 1024-element transducer
Focal Characteristics
Focal depth: None; Focal length: None; Aperture size: None
Treatment frequency
single session
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